The natural occurrence of oleamide was first reported in human serum in 1989. Please enable JavaScript to use all the features on this page. Subsequently oleamide was shown to accumulate in the cerebrospinal fluid of sleep-deprived cats and to induce sleep when administered to experimental animals. Although these important pharmacologic effects are well establish, the biochemical mechanism for the synthesis of oleamide has not yet been defined.

Oleamide also has profound effects on thermoregulation and acts as an analgesic in several models of experimental pain. The latter mechanism is discussed in the context of apoptosis where oleamide may play a role in regulating gap junction communication. Lastly, several considerations and caveats pertinent to the future study oleamide biosynthesis are discussed. ScienceDirect JavaScript is disabled on your browser.

Accordingly, oleamide first became known for its potential role in the mechanisms that mediate the drive to sleep. Chapter 3 Biosynthesis of Oleamide Show more Abstract Oleamide (cis-9-octadecenamide) is the prototype long chain primary fatty acid amide lipid messenger. ..


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